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Association of PTP4A3 expression and tumour size in functioning pituitary adenoma: a descriptive study
  1. Gabriela Deisi Moyano Crespo1,
  2. Laura Anahí Cecenarro1,
  3. Pablo Perez1,
  4. Carolina Guido1,
  5. Liliana del Valle Sosa1,
  6. Celina Berhard2,
  7. Laura Rosana Aballay3,
  8. Silvina Gutiérrez1,
  9. Juan Pablo Petiti1,
  10. Alicia Torres1,
  11. Jorge Mukdsi1
  1. 1 Instituto de Investigaciones en Ciencias de la Salud (INICSA), Centro de Microscopia Electronica-Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Cordoba, Argentina
  2. 2 Servicio de Patologia, Universidad Católica de Córdoba Clinica Universitaria Reina Fabiola, Cordoba, Argentina
  3. 3 Centro de Investigación en Nutrición Humana (CenINH), Universidad Nacional de Córdoba Facultad de Ciencias Médicas, Cordoba, Argentina
  1. Correspondence to Dr Jorge Mukdsi, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Centro de Microscopia Electronica-Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Cordoba, Argentina; mukdsijorge{at}


Background PTP4A3 is a subclass of a protein tyrosine phosphatase super family and is expressed in a range of epithelial neoplasms. We evaluated PTP4A3 expression and its association with clinicopathological parameters in different types of functioning pituitary adenomas.

Methods A total of 34 functioning pituitary adenomas samples were evaluated in this observational study. PTP4A3 expression was examined by immunohistochemical staining, and, possible correlations between PTP4A3 and some clinicopathological variables were investigated.

Results PTP4A3 was expressed in 19 out of 34 tumours (55%), at the cytoplasmic level of tumorous cells. Moreover, there was significant association (p=0.042) between PTP4A3 expression and tumorous size.

Conclusions PTP4A3 was expressed in more than half of the tumours analysed, with there being a significant association with the tumorous size of functioning adenomas. This allows to speculate that PTP4A3 may regulate tumour growth, although further investigations are necessary to determine if this phosphatase can serve as a biomarker or used as a therapeutic target in pituitary macroadenomas.

  • microscopy, electron
  • neuropathology
  • pituitary diseases
  • immunohistochemistry

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  • Handling editor Runjan Chetty.

  • Contributors All authors contributed to the design of the study, writing or critical review of the manuscript, analysis and interpretation of data. All agreed to submission of the manuscript.

  • Funding This work was supported by La Agencia Nacional de Promoción Científica y Tecnológica, Fondo Nacional de Ciencia y Tecnología (ANPCyT-FONCYT-PICT 2014-2555), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET- PIP-Res #154/2014) and Secretaria de Ciencia y Tecnología de la Universidad Nacional de Cordoba (SECyT–UNC Res # 313/2016).

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Ethics approval CIEIS del Hospital Córdoba (Registro Nacional de Investigaciones en Salud Nº CO000152 (RENIS)).

  • Provenance and peer review Not commissioned; internally peer reviewed.