Article Text

Download PDFPDF
Circulating PTHrP measurement in the assessment of severe hypercalcaemia in an infant
  1. Mark Kilbane1,
  2. Rachel Crowley2,3,
  3. Malachi McKenna1,3,
  4. Ingrid Borovickova4,
  5. Patrick J Twomey1,3
  1. 1 Clinical Chemistry, St Vincent's University Hospital, Dublin, Ireland
  2. 2 Endocrinology, St Vincent's University Hospital, Dublin, Ireland
  3. 3 School of Medicine and Medical Science, University College Dublin, Dublin, Ireland
  4. 4 Department of Biochemistry, Children's Health Ireland at Temple Street, Dublin, Ireland
  1. Correspondence to Dr Patrick J Twomey, Clinical Chemistry, St. Vincent's University Hospital, Dublin 4, Ireland; pattwomey{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Parathyroid hormone-related protein (PTHrP) can simulate most of the actions of parathyroid hormone (PTH) including increases in bone resorption and distal tubular calcium reabsorption and inhibition of proximal tubular phosphate transport.1 The low serum phosphate in parallel with low circulating PTH is consistent with PTHrP involvement in this case. Whether it can be causative for a serum calcium of 6.24 mmol/L however is a moot point. While the mechanism underlying the patient’s severe hypercalcaemia proposed by the authors is plausible, the evidence provided for PTHrP being at the root cause is not definitive. The significant differences in mRNA and PTHrP protein fragments reported between neoplastic and normal tissue does not inform on its functional status; it could be …

View Full Text


  • Handling editor Tahir S Pillay.

  • Contributors PJT was invited to provide the commentary and conceived the original idea. After discussion with PJT, MK further developed the idea and drafted the first version of the manuscript with subsequent input from all the authors. All authors provided critical feedback and helped shape the analysis and contributed to the development of each version of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

Linked Articles

  • Grand rounds
    María Julia Martín Kelly Maury Fuentes María Belén Novoa Díaz Gabriel Cao Graciela Gigola Oscar Brunetto Claudia Gentili