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Humoral hypercalcaemia in an infant: a diagnostic dilemma
  1. Bettina Chale-Matsau1,2
  1. 1 Department of Chemical Pathology, University of Pretoria Faculty of Health Sciences, Pretoria, Gauteng, South Africa
  2. 2 Chemical Pathology, National Health Laboratory Service, Pretoria, Gauteng, South Africa
  1. Correspondence to Dr Bettina Chale-Matsau, Department of Chemical Pathology, University of Pretoria Faculty of Health Sciences, Pretoria 0186, South Africa; cmatsau{at}

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Hypercalcaemia is seldom encountered in paediatric patients, and calcium levels are not routinely included in investigations. Associated symptoms such as nausea, vomiting, dehydration and abdominal pain are non-specific, thus sustained hypercalcaemia may result in delipidating calcifications, neurological and renal impairment.1 Physiologically, primary role players in calcium metabolism include parathyroid hormone (PTH) and vitamin D3 (calcitriol). It is important to establish whether hypercalcaemia is PTH or non-PTH related so that targeted treatment may be planned.

Epithelioid haemagioendothelioma (EHE) is a vascular malignant tumour that mostly affects the liver, lung, bone and soft tissue.2 Colonic EHE is uncommon. The clinical course of EHE is highly variable ranging from …

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  • Handling editor Tahir S Pillay.

  • Contributors The author herself conceptualised, drafted and wrote the manuscript.

  • Funding The author has not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

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