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Review
Pathology of IgG4-related sclerosing mastitis
  1. Polycarp Erivwo1,
  2. Gulisa Turashvili2
  1. 1Department of Pathology, Memorial University of Newfoundland, St. John's, Newfoundland, Canada
  2. 2Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
  1. Correspondence to Dr Polycarp Erivwo, Pathology, Memorial University of Newfoundland, St. John's, NL A1B 3V6, Canada; polycarp.erivwo{at}easternhealth.ca

Abstract

Immunoglobulin G4-related sclerosing mastitis (IgG4-RM) is a recently recognised member of the IgG4-related disease (IgG4-RD) family, a multisystem fibroinflammatory condition that can affect any organ system. IgG4-RM is rare and predominantly occurs in middle-aged women. It may present with painless palpable mass and/or lymphadenopathy thereby mimicking breast cancer. Although there is an abundance of literature describing the clinicopathological characteristics of IgG4-RD in a variety of organs, data on IgG4-RM are limited due to its rarity. This review describes the manifestation of the disease in the breast based on reported cases, emphasising the clinicopathological features, pathophysiology, differential diagnosis, treatment and prognosis.

  • breast diseases
  • immunoglobulins
  • inflammation

https://doi.org/10.1136/jclinpath-2020-207029

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    Footnotes

    • Handling editor Dhirendra Govender.

    • Correction notice This article has been corrected since it first published. The provenance and peer review statement has been included.

    • Contributors PE: researched the literature and developed the draft. GT: developed the idea and revised it critically for important intellectual content; provided final approval of the version to be published.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.

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