Aims S-phase kinase-associated protein 2 (Skp2) oncoprotein is overexpressed in a variety of cancer tissues and promotes the malignant development of cancer. The expression levels of chromobox homolog 7 (CBX7) protein are varied among different types of cancer tissues, but its role in cervical cancer is not clear. We aimed to examine the expression and clinical significance of Skp2 and CBX7 proteins as well as their correlations in cervical cancer.
Methods Immunohistochemistry was used to detect the expression of Skp2 and CBX7 proteins in the cancerous tissues and adjacent tissues of 64 patients with cervical cancer. Relevant clinicopathological data of these patients were collected, compared and analysed for the correlations.
Results The expression of Skp2 protein in cervical cancer (87.5%) was higher than that in paracancerous tissues (14.1%), and the expression was positively correlated with clinical stage, malignant degree, lymphatic metastasis, vascular invasion and interstitial invasion. The expression of CBX7 protein in cervical cancer (48.4%) was lower than that in paracancerous tissues (96.8%), and the expression was negatively correlated with clinical stage, malignant degree, interstitial invasion, vascular invasion and lymphatic metastasis. The expression of Skp2 protein and CBX7 protein in cervical cancer tissues and adjacent tissues was negatively correlated. The expression of Skp2 and CBX7 proteins was closely related to the clinicopathological features of cervical cancer.
Conclusions CBX7 may play the role of a tumour suppressor gene in cervical cancer and provide reference value for the diagnosis and new targeted treatment of cervical cancer.
- cervix uteri
Data availability statement
Data are available upon reasonable request.
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Handling editor Mona El-Bahrawy.
GM, PT, HM, LD and CM contributed equally.
Contributors RL, LD and CM conceived and designed the experiments. PT, YL and JW gathered information. GM, HM and PT performed the experiments. GM, QY and HM analysed the data. GM wrote the paper.
Funding This project is supported by the National Natural Science Foundation of China (81760468 and 82060468); the Postdoctoral Science Foundation of China (2019M663964XB); the Science and Technology Programme of Higher Education of Xinjiang Uygur Autonomous Region (XJEDU2018Y028); and the State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia Fund (SKL-HIDCA-2018-16 and SKL-HIDCA-2020-WF1).
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.