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Conjunctival squamous intraepithelial neoplasia and its differential diagnosis
  1. Alexander Reese1,
  2. Curtis Edward Margo2
  1. 1 Pathology and Cell Biology, USF Health Morsani College of Medicine, Tampa, Florida, USA
  2. 2 Pathology and Cell Biology, and Ophthalmology, Morsani College of Medicine, Tampa, Florida, USA
  1. Correspondence to Dr Curtis Edward Margo, Dermatopathology, USF Health Morsani College of Medicine, Tampa, Florida 33612, USA; cmargo{at}


Conjunctival squamous intraepithelial neoplasia (CSIN) represents the in situ precursor of squamous cell carcinoma. The graded severity of intraepithelial dysplasia is considered a measure of risk for progression to invasive carcinoma. The range of cytoarchitectural changes in CSIN overlaps those of reactive atypia, squamous epithelial papilloma and in situ sebaceous carcinoma. Pseudoepitheliomatous hyperplasia and benign hereditary dyskeratosis of the conjunctiva are conditions without risk of neoplastic transform that are potentially mistaken for CSIN.

  • carcinoma
  • neoplasms
  • pathology
  • surgical

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  • Handling editor Tahir S Pillay.

  • Contributors Each author has contributed to researching, writing, editing and illustrating this paper, including the revised paper.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.