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Gene of the month: NKX3.1
  1. Jon Griffin1,2,
  2. Yuqing Chen3,
  3. James W F Catto4,5,
  4. Sherif El-Khamisy2
  1. 1 Histopathology Department, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
  2. 2 Healthy Lifespan and Neuroscience Institute, Department of Biosciences, The University of Sheffield, Sheffield, UK
  3. 3 Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK
  4. 4 Academic Urology Unit, The University of Sheffield, Sheffield, UK
  5. 5 Urology Department, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
  1. Correspondence to Dr Jon Griffin, Histopathology Department, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK; jon.griffin{at}nhs.net

Abstract

NKX3.1 is a multifaceted protein with roles in prostate development and protection from oxidative stress. Acting as a pioneer factor, NKX3.1 interacts with chromatin at enhancers to help integrate androgen regulated signalling. In prostate cancer, NKX3.1 activity is frequently reduced through a combination of mutational and post-translational events. Owing to its specificity for prostate tissue, NKX3.1 has found use as an immunohistochemical marker in routine histopathology practice.

  • prostate
  • immunohistochemistry
  • receptors
  • steroid

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Footnotes

  • Handling editor Runjan Chetty.

  • Contributors JG and YC performed the literature search and created the figures, all authors wrote and edited the manuscript.

  • Funding JG is funded by a Clinical PhD Fellowship from The Pathological Society of Great Britain and Ireland, and The Jean Shanks Foundation (JSPS-CPHD-2018–01). JWFC is funded by an NIHR Research Professorship. SE-K is funded by a Wellcome Trust Investigator Award (103844) and a Lister Institute of Preventative Medicine Fellowship (137661).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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