NKX3.1 is a multifaceted protein with roles in prostate development and protection from oxidative stress. Acting as a pioneer factor, NKX3.1 interacts with chromatin at enhancers to help integrate androgen regulated signalling. In prostate cancer, NKX3.1 activity is frequently reduced through a combination of mutational and post-translational events. Owing to its specificity for prostate tissue, NKX3.1 has found use as an immunohistochemical marker in routine histopathology practice.
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Handling editor Runjan Chetty.
Contributors JG and YC performed the literature search and created the figures, all authors wrote and edited the manuscript.
Funding JG is funded by a Clinical PhD Fellowship from The Pathological Society of Great Britain and Ireland, and The Jean Shanks Foundation (JSPS-CPHD-2018–01). JWFC is funded by an NIHR Research Professorship. SE-K is funded by a Wellcome Trust Investigator Award (103844) and a Lister Institute of Preventative Medicine Fellowship (137661).
Competing interests None declared.
Provenance and peer review Not commissioned; internally peer reviewed.
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