GATA binding protein 3 (GATA3) is a zinc-finger pioneer transcription factor involved in diverse processes. GATA3 regulates gene expression through binding nucleosomal DNA and facilitating chromatin remodelling. Post-translational modifications modulate its activity. During development, GATA3 plays a key role in cell differentiation. Mutations in GATA3 are linked to breast and bladder cancer. GATA3 expression is a feature of the luminal subtype of bladder cancer and has implications for immune status and therapeutic response. It also has clinical relevance in squamous cell carcinomas and soft tissue sarcomas. This paper reviews the structure and function of GATA3, its role in cancer and its use and pitfalls as an immunohistochemical marker.
- molecular biology
- breast neoplasms
- urologic neoplasms
- pathology, molecular
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Handling editor Murali Varma.
Contributors ZQ, JG: literature review; KL, IJ, JG: figures and histopathology images; all authors: manuscript design and writing/editing of critical intellectual content.
Funding JG is funded by an NIHR Clinical Lectureship and Cancer Research UK Translational Sample Collection Grant (CRCPSC-Nov22/100002).
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.