Adipophilin (ADRP/ADPH/PLIN2), an adipocyte differentiation-related protein, is highly expressed at a very early time during the differentiation of adipocytes. It assists in the formation and maintenance of intracellular lipid droplets and plays a role in regulating the physiological functions of the body. More and more studies indicate that it is involved in the occurrence and development of a variety of glycolipid metabolic diseases and tumours. In this review, we comprehensively stated the expression and functions of adipophilin and introduced its roles in physiology and pathology.
- pathology, molecular
- skin diseases
- pathology, surgical
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Handling editor Runjan Chetty.
Contributors F-ZL and SF: Conceptualisation. F-ZL and SF: Writing of the manuscript—original draft. F-ZL and SF: Writing of the manuscript—review and editing. All authors have read and agreed to the published version of the manuscript.
Funding Our research associated with this review was supported by the Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau), (2022QNXM014).
Competing interests None declared.
Provenance and peer review Commissioned; externally peer reviewed.