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Haemolysis index conundrum in a COVID-19 patient
  1. Chong Qin Michael Zhao1,
  2. Jordan Steinberg2,
  3. Dennise Otero Espinal3,
  4. Oana Vele3
  1. 1 Pathology and Laboratory Medicine, Northwell Health North Shore University Hospital, Manhasset, New York, USA
  2. 2 Pathology, Mount Sinai South Nassau, Oceanside, New York, USA
  3. 3 Pathology and Laboratory Medicine, Northwell Health Lenox Hill Hospital, New York, New York, USA
  1. Correspondence to Dr Oana Vele; ovele{at}northwell.edu

Abstract

In this study, we report a preanalytical challenge noted in our laboratory on plasma samples from a critically ill COVID-19 patient treated with hydroxychloroquine. This is significant because, in critically ill COVID-19 patients on hydroxychloroquine, plasma samples can have a high measured haemolysis index in the absence of haemolysis, with the impact on reporting the results for potassium and other analytes.

  • Anemia, Hemolytic
  • COVID-19
  • Chemistry, Clinical

https://doi.org/10.1136/jcp-2023-209196

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    Footnotes

    • Handling editor Patrick J Twomey.

    • Contributors CQMZ: conceptualisation, formal analysis, investigation and writing the original draft. JS: formal analysis and reviewing the manuscript. DOE: formal analysis, reviewing the manuscript and revising the original draft. OV: conceptualisation, formal analysis, investigation and revising the original draft.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.

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