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RB1: governor of the cell cycle in health and disease—a primer for the practising pathologist
  1. Fleur Cordier,
  2. David Creytens
  1. Department of Pathology, Ghent University Hospital, Ghent, Belgium
  1. Correspondence to Dr David Creytens, Department of Pathology, Ghent University Hospital, Ghent, Belgium; david.creytens{at}


RB1 stands as the pioneering discovery in tumour-suppressor genes, marking a pivotal breakthrough in comprehending cancer development. This overview delves into the role of RB1 in both health and disease, exploring its association with the tumourigenesis of various cancers and a distinct subset of soft-tissue neoplasms. Additionally, we discuss the application of immunohistochemistry and fluorescence in situ hybridisation to detect RB1 alterations.

  • Pathology, Molecular
  • Soft Tissue Neoplasms

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  • Handling editor Vikram Deshpande.

  • Contributors FC performed the writing of the paper and made the figures. The authors performed the study concept, design and review of the paper. All authors read and approved the final paper.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests One of the coauthors (DC) is an editor of the Journal of Clinical Pathology. The other author (FC) declares no potential conflicts of interest with respect to the research, authorship and/or publication of this article.

  • Provenance and peer review Commissioned; externally peer reviewed.