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Omeprazole-associated changes in the gastric mucosa of children
  1. Ricardo Drut (patologi{at}
  1. Hospital de Niños, Argentina
    1. Eugenia Altamirano (aleu{at}
    1. Hospital de Niños, Argentina
      1. Eduardo Cueto Rúa (cuetorua{at}
      1. Hospital de Niños, Argentina


        Aims: To describe histologic findings in gastric mucosa biopsies of children treated with proton-pump inhibitor (PPI) for different periods of time. Methods: samples of 12 children (4m-15y) treated with PPI and 8 controls were processed for paraffin embedding and stained with H&E as well as inmmunohistochemically for Sialyl-Tn antigen. Results: Main changes were related to parietal cells which showed brisk cytoplasmic eosinophilia, apical cytoplasmic protrusions to dilated glands, cytoplasmic and nuclear hypertrophy, dilated intracytoplasmic canaliculi, and bi and multinucleation. The intracellular canaliculi surface showed strong immunohistochemical reaction for Sialyl-Tn antigen, apparently a marker for this structure. As some of the patients were biopsied after a short period of per os or intravenously administered omeprazole it seems that the changes may install very fast. Conclusions: PPI induces the same changes in the gastric mucosa of children as reported in adults, but the increased number of nuclei. There is no previous report referring these findings of PPI effect on the gastric mucosa at this age. It is suggested that these result from the combination of PPI effect and gastrin release.

        • gastric mucosa
        • omeprazole
        • parietal cell
        • proton-pump inhibitors

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