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Acute enterovirus infection followed by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and viral persistence.
  1. john K Chia1,*,
  2. Andrew Y Chia1,
  3. Michael Voeller2,
  4. Tonney M Lee3,
  5. Robert Chang4
  1. 1 EV Med Research, United States;
  2. 2 Torrance Memorial Medical Center, United States;
  3. 3 South Bay Gastroenterology Medical Group, United States;
  4. 4 Pennisula pulmonary Institute, United States
  1. Correspondence to: , ; evmed{at}


A number of infections have been associated with myalgia encephalomyelitis/chronic fatigue syndrome (ME/CFS). Often occurring in epidemics, enteroviruses are significant causes of respiratory, gastrointestinal infections, non-specific flu-like illnesses, and many disseminated infections. It has been difficult to demonstrate causality for chronic diseases without having well-documented cases of acute enterovirus infections. In this report, we described 3 patients presenting with acute enterovirus infections, which were followed by ME/CFS, and the persistent viral infections were demonstrated by finding enterovirus VP1 protein and RNA in the stomach.

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