Footnotes

• Contributors All authors participated in the evaluation and management of this case, acquisition of data or analysis and interpretation of data, drafting and revising the manuscript. All authors approve the version of the manuscript being submitted. GL: The first and corresponding author, initiated and conducted the project, reviewed and conducted cytogenetics studies, and wrote the manuscript. RAS: Performed tCGH to identify EVT6/FLT3 rearrangement and edited the manuscript. CEB-R: Performed immunohistochemistry for FLT3 expression, interpreted data and contributed to the writing of the manuscript. JEC. Contributed reagents and to the writing of the manuscript. XIW: Interpreted data and contributed to the writing of the manuscript. LJM: Interpreted data and contributed to the writing of the manuscript. CCY: Interpreted data, contributed figures and contributed to the writing of the manuscript.

• Competing interests None.

• Ethics approval IRB, UT MD Anderson Cancer center, PA11-0397.

• Provenance and peer review Not commissioned; externally peer reviewed.