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There have been many recent developments in thyroid fine-needle aspiration (FNA). Thyroid fine-needle aspiration was traditionally practised freehand although in recent years the majority of thyroid fine-needle aspirations are now taken under ultrasound guidance.1 While thyroid fine-needle aspiration practice has changed relatively little, new molecular technologies have developed apace. The principal new technology is the application of molecular markers to thyroid fine-needle aspirates.2 The prototypical marker is BRAF V600E. Mutations of the BRAF V600 gene in thyroid cancer were described over 10 years ago and are quite common in thyroid cancer, melanoma and adenocarcinomas, such as lung and colorectal tumours.3 Mutation of the BRAF V600E within primary tumours of the …
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