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Original article
New tumour antigen PLAC1/CP1, a potentially useful prognostic marker and immunotherapy target for gastric adenocarcinoma
  1. Fangfang Liu1,
  2. Danhua Shen1,
  3. Xiaoping Kang2,
  4. Chunfang Zhang3,
  5. Qiujing Song1
  1. 1Department of Pathology, Peking University People's Hospital, Beijing, China
  2. 2Department of Statistics Office, Peking University Health Science Center, Beijing, China
  3. 3Department of Clinical Epidemiology, Peking University People's Hospital, Beijing, China
  1. Correspondence to Professor Fangfang Liu, Department of Pathology, Peking University People's Hospital, Beijing 100044, China; liufangfang{at}pkuph.edu.cn

Abstract

Aim To evaluate protein expression and clinical significance of PLAC1/CP1 antigen in primary gastric adenocarcinoma.

Methods Protein expression of PLAC1/CP1 was analysed by tissue chip and immunohistochemistry in surgical specimens obtained from 119 patients with gastric cancer. The data were analysed using SPSS V.16.0 software applying the χ2 test and Kaplan-Meier method.

Results The positive expression frequency of PLAC1/CP1 protein was 61.3% (73/119 patients). The overall survival of patients with PLAC1/CP1 protein-positive expression was significantly lower than that of patients with PLAC1/CP1 protein-negative expression (p<0.05). There was no significant relationship between PLAC1/CP1 expression and patient gender, age, tumour position, tumour size, differentiation, gross type, lymph node or TNM stage.

Conclusions PLAC1/CP1 protein is expressed in over half of cases of primary gastric cancer, and PLAC1/CP1 protein expression is inversely correlated with patient survival. The data indicate that PLAC1/CP1 provides a marker for identifying gastric cancers with poor prognosis, and suggest that PLAC1/CP1 may provide a useful target for immunotherapy.

  • GASTRIC CANCER
  • PROTEINS
  • TUMOUR MARKERS
  • IMMUNOHISTOCHEMISTRY
  • TUMOUR IMMUNITY

https://doi.org/10.1136/jclinpath-2015-202978

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