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Review
Hippo pathway deregulation: implications in the pathogenesis of haematological malignancies
  1. Maira da Costa Cacemiro,
  2. Maria Gabriela Berzoti-Coelho,
  3. Juçara Gastaldi Cominal,
  4. Sandra Mara Burin,
  5. Fabíola Attié de Castro
  1. Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo—USP, Ribeirão Preto, São Paulo, Brazil
  1. Correspondence to Maira da Costa Cacemiro, Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo—USP, Av. do Café, s/n°. Campus Universitário, Ribeirão Preto, São Paulo 14040-903, Brasil; mairacacemiro{at}hotmail.com

Abstract

The Hippo pathway participates in the regulation of cell proliferation, differentiation and apoptosis. It is composed by a large array of proteins whose deregulation has been associated with pro-oncogenic and antioncogenic processes. The present review focuses on the Hippo pathway signalling network and discusses its dual role in oncogenesis, particularly in haematological malignancies.

  • APOPTOSIS
  • ONCOGENES
  • HAEMATO-ONCOLOGY
  • CANCER
  • CELL CYCLE REGULATION

https://doi.org/10.1136/jclinpath-2016-204055

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    Footnotes

    • Handling editor Mary Frances McMullin

    • Contributors MCC, JGC, MGBC and SMB contributed equally to conceive and write this review. FAC supervised and critically discussed the review. All authors read and approved the final manuscript.

    • Funding This work was supported by the São Paulo Research Foundation (FAPESP, grants #2014/04234-9; #2015/23555-3; #2015/25637-7), the National Council for Scientific and Technological Development (CNPq) and Coordination for the Improvement of Higher Education Personnel (Capes).

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.