The Hippo pathway participates in the regulation of cell proliferation, differentiation and apoptosis. It is composed by a large array of proteins whose deregulation has been associated with pro-oncogenic and antioncogenic processes. The present review focuses on the Hippo pathway signalling network and discusses its dual role in oncogenesis, particularly in haematological malignancies.
- CELL CYCLE REGULATION
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Handling editor Mary Frances McMullin
Contributors MCC, JGC, MGBC and SMB contributed equally to conceive and write this review. FAC supervised and critically discussed the review. All authors read and approved the final manuscript.
Funding This work was supported by the São Paulo Research Foundation (FAPESP, grants #2014/04234-9; #2015/23555-3; #2015/25637-7), the National Council for Scientific and Technological Development (CNPq) and Coordination for the Improvement of Higher Education Personnel (Capes).
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.