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Clinical question
A 45-year-old woman is found, on family history screening, to have calcification within the upper outer quadrant of her right breast. A diagnostic mammotome biopsy was performed. Review the interactive digital slide and consider your diagnosis and appropriate management.
What is your diagnosis?
Collagenous spherulosis
Flat epithelial atypia with psammomatous calcification
Liesegang rings with lactational changes
Parasitic infection
Spheroid type amyloid
Discussion
Answer: C
Histologically, there are focal collections of dilated ducts and microcysts lined by vacuolated epithelium showing lactational change. Many rounded concentric calcifications of various sizes are seen within the ductal lumina. These show characteristic appearances of Liesegang rings. In some ducts, the rings surround amorphous material with histologically identifiable calcific deposits. A mild chronic inflammatory infiltrate is seen in-between ducts.
Liesegang rings are spherical, ring-like …
Footnotes
Handling editor Iskander Chaudhry
Contributors AR and AS diagnosed the lesion, searched the literature and contributed to the writing up. Both authors approved the final manuscript.
Competing interests None.
Provenance and peer review Commissioned; internally peer reviewed.
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