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  1. Stefano Serra,
  2. Runjan Chetty
  1. Department of Anatomic Pathology, Laboratory Medicine Program, University Health Network and University of Toronto, Toronto, Canada
  1. Correspondence to Dr Stefano Serra, Department of Pathology, University Health Network, Toronto General Hospital, Toronto, Ontario M5G 2C4, Canada; stefano.serra{at}


RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation. Loss of function of RNF43 results in decrease/lack of degradation of Frizzled with enhancement of Wnt/β-catenin signaling pathway. Mutations of RNF43 have been reported in different cancers. We describe the structure of RNF43, its function and most frequent mutations in different cancers.

  • gi neoplasms pancreatic
  • cancer
  • colorectal cancer

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  • Handling editor Cheok Soon Lee

  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

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