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Correspondence
Transformation of a splenic marginal zone lymphoma into classic Hodgkin lymphoma
  1. Thomas Menter,
  2. Stefan Dirnhofer,
  3. Alexandar Tzankov
  1. Institute of Pathology, University Hospital Basel, Basel, Switzerland
  1. Correspondence to Professor Alexandar Tzankov, Institute of Pathology, University Hospital Basel, Basel 4031, Switzerland; alexandar.tzankov{at}usb.ch

https://doi.org/10.1136/jclinpath-2018-205678

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    Sir,

    Transformation of marginal zone lymphoma (MZL) to aggressive lymphoma is considered a rare event with most cases evolving into diffuse large B-cell lymphoma (DLBCL).1 Here, we present a case of splenic MZL (sMZL) transforming into classic Hodgkin lymphoma (cHL).

    A patient, with a history of IgD-positive sMZL and treated with several cycles of rituximab and bendamustine and radiotherapy of the spleen, presented 2 years after initial diagnosis with bone pain due to osteolysis of the Os ilium. An imaging-guided bone biopsy revealed infiltrates of cHL (figure 1) while the patient still had residual histologically documented sMZL in the spleen …

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    Footnotes

    • Handling editor Mary Frances McMullin.

    • Provenance and peer review Not commissioned; externally peer reviewed.