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Intraoperative frozen section consultation by remote whole-slide imaging analysis –validation and comparison to robotic remote microscopy
  1. Thomas Menter,
  2. Stefan Nicolet,
  3. Daniel Baumhoer,
  4. Markus Tolnay,
  5. Alexandar Tzankov
  1. Institute of Pathology and Medical Genetics, University Hospital Basel, Basel, Switzerland
  1. Correspondence to Professor Alexandar Tzankov, Pathology, University Hospital Basel, Basel 4031, Switzerland; alexandar.tzankov{at}


Digital pathology including whole slide image (WSI) acquisition is a promising tool for histopathologic teleconsultation. To test and validate the use of WSI in comparison with robotic microscopy for intraoperative frozen section consultation of peripheral hospitals serviced by our department, we compared the VENTANA DP 200 slide scanner with an established remote-controlled digital microscope. Thirty cases were retrospectively analysed. In comparison with a median specimen handling time of 19 min using remote-controlled microscopy, the WSI handling was significantly shorter (11 min, p=0.0089) and offered better image quality, for example, allowing to detect a positive resection margin by a malignant melanoma that had been missed using the former system. Prospectively assessed on 12 cases, the median handling time was 6 min. Here, we demonstrate the applicability and the advantages of WSI for intraoperative frozen section teleconsultation. WSI-based telepathology prooves to be an efficient and reliable tool providing superior turn-around time and image resolution.

  • digital pathology
  • telepathology
  • surgical pathology

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  • Handling editor Runjan Chetty.

  • Presented at SGPath Annual Meeting November 7-9 2019, Lucerne, Switzerland

  • Contributors TM, DB, MT and AT: designed the study. TM and SN: performed the accrual of the data of the retrospective analysis. TM and AT: accrued the data of the iPath cases and the prospective cases using the Ventana Image Viewer. TM: wrote the manuscript. All authors read and approved the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; internally peer reviewed.