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Adiponectin and adiponectin receptor 1 expression proteins levels are modified in breast cancer in postmenopausal women with obesity
  1. Leticia Orozco-Arguelles1,2,
  2. Sergio De los Santos1,2,
  3. Alberto Tenorio-Torres3,
  4. Juan Pablo Méndez1,2,
  5. Marcela Leal-García1,2,
  6. Ramón Coral-Vázquez4,5,
  7. Claudia Vega-García6,
  8. Verónica Bautista-Piña3,
  9. María Elena Tejeda1,2,
  10. Eduardo Cárdenas-Cárdenas1,2,
  11. Patricia Canto1,2
  1. 1Unidad de Investigación en Obesidad, Facultad de Medicina, Universidad Nacional Autonoma de México, Ciudad de México, México
  2. 2Subdirección de Investigación Clínica, División de Investigación, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Ciudad de México, México
  3. 3Instituto de Enfermedades de la Mama, FUCAM, Ciudad de México, México
  4. 4Sección de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México, México
  5. 5Subdirección de Enseñanza e Investigación, Centro Médico Nacional "20 de Noviembre", Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Ciudad de México, México
  6. 6Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubiran", Ciudad de México, México
  1. Correspondence to Dr Patricia Canto, Unidad de Investigación en Obesidad, Universidad Nacional Autónoma de México, Ciudad de México 14000, Mexico; ipcanto{at}yahoo.com.mx

Abstract

Aim To analyse the expression of adiponectin (ADIPOQ), and its receptors ADIPOR1 and ADIPOR2, in breast cancer tissue of postmenopausal women with different body mass indexes (BMIs).

Subjects and methods One hundred and fifty postmenopausal Mexican-Mestizo women with breast cancer were included. BMI was determined in each case. To carry out qualitative and semiquantitative assessments of protein expression by immunohistochemistry, the H-Score method was used, through ImageJ's IHC Profiler software. Statistical power of the study was >80% with a p<0.05.

Results Fifty women had a normal BMI, 50 presented overweight and 50 had obesity. The expression of ADIPOQ in breast cancer tissue of postmenopausal woman with normal BMI was higher in comparison to women with overweight or with obesity (p=0.002 and p<0.001, respectively). Furthermore, the expression of ADIPOR1 in breast cancer tissue of postmenopausal women with normal BMI was significantly lower when compared with women with overweight or with obesity (p=0.005 and p<0.001, respectively). Meanwhile, the expression of ADIPOR2 in breast cancer tissue, in the cytoplasm, was similar in all groups studied.

Conclusions We found that women with overweight or obesity had a lower expression of ADIPOQ and a higher ADIPOR1 expression in breast cancer tissue, when compared with women with a normal BMI.

  • breast cancer
  • breast pathology
  • endocrinology
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Footnotes

  • Handling editor Cheok Soon Lee.

  • LO-A and SDlS contributed equally.

  • Contributors LO-A performed all the experiments, analysis of results and gave final approval of the version to be published. SDlS helped in study design, performed all the experiments, analysis and interpretation of results, manuscript elaboration and final approval of the version to be published. AT-T helped in study design, inclusion of patients and clinical studies and gave final approval of the version to be published. JPM helped in the study design, manuscript elaboration and gave final approval of the version to be published. ML-G helped in inclusion of patients and clinical studies and gave final approval of the version to be published. RC-V helped in design of all experiments and studies, manuscript elaboration and gave final approval of the version to be published. CV-G helped in study design, performed the experiments and gave final approval of the version to be published. VB-P helped in study design, pathology analysis and gave final approval of the version to be published. MET performed all the experiments, analysis of results and gave final approval of the version to be published. EC-C performed all statistical analysis and gave final approval of the version to be published. PC helped in grant obtention, design of all experiments and studies, interpretation of the results, manuscript elaboration and gave final approval of the version to be published.

  • Funding This work was supported by the Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica PAPIIT, Dirección General de Asuntos del Personal Académico, DGAPA, Universidad Nacional Autónoma de México (Grant IA204617).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval Human Research Committees of the Universidad Nacional Autónoma de México and Instituto de Enfermedades de la Mama, FUCAM (Number 037/2014) approved the study.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article.

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