Article Text

Download PDFPDF
Gene of the month: TLE 1
  1. Karen Pinto1,
  2. Runjan Chetty2
  1. 1Pathology, Kuwait Cancer Control Center, Shuwaikh, Al Asimah, Kuwait
  2. 2Department of Histopathology, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK
  1. Correspondence to Professor Runjan Chetty, Department of Histopathology, Brighton and Sussex University Hospitals NHS Trust, Brighton BN2 5BE, UK; runjan.chetty{at}


TLE 1 is the human homologue belonging to a family of four genes and is located on chromosome 9q21. It consists of 19 exons. Although it does not bind directly to DNA, it acts as a repressor of several signalling pathways via transcription factors. TLE1 protein has several physiological roles in embryogenesis, haematopoiesis, general differentiation, and both neuronal and eye development. Much attention was focused on its expression in the tumour cell nuclei of synovial sarcoma (SS). However, several other soft tissue tumours that do and do not share morphological similarity with SS also display nuclear immunoreactivity for TLE1; hence, caution in interpretation is advocated.

  • genetics
  • biomarkers
  • tumour
  • oncogenes
  • immunohistochemistry
View Full Text

Statistics from


  • Handling editor Dhirendra Govender.

  • Twitter @runjanchetty

  • Contributors KP and RC contributed equally to concept, collation of data, design and writing of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests RC is a consultant for Deciphex Ltd, Ireland.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.