Introduction Large granular lymphocyte (LGL) leukaemia is considered a mature T-cell or natural killer (NK) cell neoplasm, characterised by a clonal proliferation of LGL.
Aims To analyse the characteristics and to establish (if possible) the prognostic parameters of these patients diagnosed in a single centre: University Hospital of Donostia.
Methods We retrospectively studied data about 308 patients with LGL leukaemia diagnosed in our centre.
Results The frequency of T-LGL leukaemia and chronic lymphoproliferative disorder of NK cells was 89% and 6.8% respectively, and no aggressive NK-LGL leukaemia was seen in our population. The median age at diagnosis was 65.7 years and male-to-female ratio was 1.08. 59% of our patients were asymptomatic at the time of diagnosis. Most patients presented lymphocytosis and 63.6% more than 20% LGLs in the peripheral blood count, but it has to be taken into account that these results may be influenced by the selection bias of our study, as we recognised these patients as ‘alarms of the laboratory analysers’. Neutropenia was the most common cytopenia, and autoimmune disorders were described in 16.5% of the patients. Only 12 patients (3.9%) required treatment, a much lower percentage that the one reported in the literature, and this is consistent with the fact that patients were less symptomatic than in other series, as we expected. The 5-year and 15-year overall survival was 92% and 87%, respectively.
Conclusions Our patients may represent the even more benign end of the spectrum of clonal T LGL and NK proliferations.
- haematologic diseases
- lymphoid tissue
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Handling editor Mary Frances McMullin.
Contributors AU, MA, CG and JRF designed the study. AU, NR and JRF prepared the manuscript. AU, CG, NR, MR, LA, MDDJ and AA contributed to data collection, and IU contributed to statistical analysis.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Not required.
Ethics approval Previous to the data collection, the study was approved by the clinical research ethics committee (CEIC) of the health area of Gipuzkoa, according to the law 14/2007 of Biomedical research, ethical principles of the Declaration of Helsinki and other applicable ethical principles.
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement Data are available upon reasonable request.
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