Multiple myeloma (MM) genomic complexity reflects in the variable patients’ clinical presentation. Genome-wide studies seem to be a reasonable alternative to identify critical genomic lesions. In the current study, we have performed the genomic characterisation of a Portuguese cohort of patients with MM by array comparative genomic hybridisation. Overall, the most frequently detected alterations were 13q deletions, gains of 1q, 19p, 15q, 5p and 7p and trisomy 9. Even though some identified genomic alterations were previously associated with a prognostic value, other abnormalities remain with unknown, but putative significance for patients’ clinical practice. These genomic alterations should be further assessed as possible biomarkers.
- microarray analysis
- multiple myeloma
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Handling editor Mary Frances McMullin.
ACO and IPR contributed equally.
Contributors ACO, IPR, LMP, ACG, AP, CG and AR performed the acquisition, analysis and interpretation of the data; CG, AR and ABS-R performed sample collection; ACO wrote the manuscript; ABS-R, JBdM and IMC designed the study. All authors reviewed critically and approved the manuscript.
Funding This work was funded by the oncology research grant NRC-LPCC/CIMAGO, Project: Genomic Characterization of Monoclonal Gammopathies Patients.
Competing interests None declared.
Patient consent for publication Not required.
Ethics approval This study was approved by ethics committee of the Faculty of Medicine of the University of Coimbra. Sample collection and clinical profile information were provided after written informed consent, in accordance with the Declaration of Helsinki.
Provenance and peer review Not commissioned; externally peer reviewed.
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