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Clinicopathological characteristic of ciliated muconodular papillary tumour of the lung
  1. Yong Yang1,
  2. Xiaofeng Xie2,
  3. Gening Jiang1,
  4. Liping Zhang2,
  5. Hongcheng Liu1
  1. 1Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
  2. 2Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
  1. Correspondence to Hongcheng Liu, Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, No. 507 Zhengmin Road, Shanghai, 200433, China; lhcsz{at}163.com; Liping Zhang, Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, No. 507 Zhengmin Road, Shanghai, 200433, China; lipingzhang2002{at}outlook.com

Abstract

Aims Ciliated muconodular papillary tumour (CMPT) is a rare tumour characterised by tripartite cellular components of mucinous cells, ciliated columnar cells and basal cells with a predominantly papillary architecture. Its clinicopathological characteristics and treatment methods have not been fully elucidated.

Methods Twenty-six patients with CMPT diagnosed and treated in our hospital were retrospectively analysed.

Results The cohort was composed of 13 males and 13 females, with a mean age of 64.4±5.93 years. The diameter of the primary tumour ranged from 0.3 to 1.4 cm. The lesions appeared as subsolid nodules, ground-glass nodules and cavitary nodules under the CT scan. All the patients underwent surgical treatment and did not receive postoperative adjuvant therapy. All the CMPTs were diagnosed by immunohistochemistry and not by intraoperative frozen sections. Next-generation sequencing detection demonstrated EGFR, KRAS and BRAF mutations and ALK rearrangements in CMPTs. The follow-up duration ranged from 5 to 65 months, and no case of tumour recurrence was observed until the final follow-up.

Conclusions The incidence of CMPT is low, and the prognosis is good. Immunohistochemistry is helpful for an accurate diagnosis of CMPT, while intraoperative frozen sections cannot fully guide the surgical method. Sublobectomy may be enough without adjuvant treatment. CMPTs exhibited a relatively high rate of driver gene mutations, while the mutation sites were not consistent with those in lung adenocarcinoma.

  • lung neoplasms
  • general surgery
  • genetics

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Footnotes

  • Handling editor Runjan Chetty.

  • YY and XX contributed equally.

  • Contributors YY prepared the manuscript and made statistical analysis. XX provided the pathology image. GJ provided the clinical patient database. LZ checked the pathology image and diagnosis. HL designed the study and revised the manuscript.

  • Funding This work was supported by the National Natural Foundation of China grant 81500060, Tongji University Youth Excellent Talents Training Action Plan grant 2016KJ069 and Shanghai Association for Science and Technology Foundation grant 19ZR1442900.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon reasonable request. Data are available from the authors.

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