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Gene of the month: Cornulin
  1. Rajandeep Kaur1,
  2. Anshika Chauhan1,
  3. Shabir Ahmad Bhat1,
  4. Debajyoti Chatterjee2,
  5. Sushmita Ghoshal3,
  6. Arnab Pal1
  1. 1Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, India
  2. 2Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
  3. 3Radiotherapy, Post Graduate Institute of Medical Education and Research, Chandigarh, India
  1. Correspondence to Dr Arnab Pal, Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India; pal.arnab{at}


Cornulin (CRNN) gene encodes a 495 amino acid long protein and is located on chromosome 1q21.3. Primarily, it functions as the marker of differentiation. Initially, it was found to be specific for the squamous cells of oesophagus. However, later on, several studies have revealed the presence of Cornulin downregulation in various epithelial squamous cell carcinomas of the head and neck, oesophagus and cervix and clinically associated it with worsening of cancer and the poor prognosis. Cornulin levels also showed dysregulation in other diseases such as Eczema and Psoriasis. Besides the differentiation marker, it was identified to be involved in the stress response. The studies, in psoriasis and oesophageal squamous cell carcinoma, has elucidated that the dysregulation in the Cornulin is associated with the cell cycle events such as G1/S transition. However, the actual function of Cornulin is still yet to be explored in detail.

  • biomarkers
  • tumor
  • carcinoma
  • pathology
  • molecular

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  • Handling editor Runjan Chetty.

  • Contributors Conception and design: RK, AC and AP. Drafting of the article: RK and AC. Critical revision of the article for important intellectual content: SAB, DC, SG and AP. Final approval of the article: AP. All authors approved the final version of the article.

  • Funding Council of Scientific and Industrial Research: 09/141 (0209)/2019; 09/141 (0210)/2019. Indian Council of Medical Research: No.5/13/74/2020/NCD-III. Department of Science and Technology, Ministry of Science and Technology, Science and Engineering Research Board: CRG/2020/001532.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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