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Adrenal insufficiency
  1. Rajeev Kumar1,
  2. W S Wassif2
  1. 1Diabetes and Endocrinology, Bedfordshire Hospitals NHS Foundation Trust, Bedford, UK
  2. 2Clinical Biochemistry, Bedfordshire Hospitals NHS Foundation Trust, Bedford, UK
  1. Correspondence to Dr Rajeev Kumar, Diabetes and Endocrinology, Bedfordshire Hospitals NHS Foundation Trust, Bedford MK42 9DJ, UK; Rajeev.Kumar{at}bedfordhospital.nhs.uk

Abstract

Adrenal insufficiency (AI), first described by Thomas Addison in 1855, is characterised by inadequate hormonal production by the adrenal gland, which could either be primary, due to destruction of the adrenal cortex, or secondary/tertiary, due to lack of adrenocorticotropic hormone or its stimulation by corticotropin-releasing hormone. This was an invariably fatal condition in Addison’s days with most patients dying within a few years of diagnosis. However, discovery of cortisone in the 1940s not only improved the life expectancy of these patients but also had a dramatic effect on their overall quality of life. The diagnosis, easily confirmed by demonstrating inappropriately low cortisol secretion, is often delayed by months, and many patients present with acute adrenal crisis. Sudden withdrawal from chronic glucocorticoid therapy is the most common cause of AI. Currently, there remains a wide variation in the management of this condition across Europe. As primary AI is a relatively rare condition, most medical specialists will only manage a handful of these patients in their career. Despite many advances in recent years, there is currently no curative option, and modern cortisol replacement regimens fail to adequately mimic physiological cortisol rhythm. A number of new approaches including allograft of adrenocortical tissue and stem cell therapy are being tried but remain largely experimental.

  • adrenal glands
  • aldosterone
  • endocrinology
  • endocrine system diseases

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Footnotes

  • Handling editor Patrick J Twomey.

  • Contributors RK and WSW contributed to the conception and design of the paper, and RK wrote the first draft. Both authors gave their approval for the final version of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; externally peer reviewed.

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