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New kids on the block: FOS and FOSB gene
  1. Fleur Cordier,
  2. David Creytens
  1. Department of Pathology, Ghent University Hospital, Ghent, Belgium
  1. Correspondence to Dr David Creytens, Pathology, Ghent University Hospital, Ghent, Belgium; david.creytens{at}


FOS and FOSB proto-oncogens are involved in a wide variety of tumourigenic processes. FOS and FOSB gene rearrangements are observed in epithelioid haemangioma, pseudomyogenic haemangioendothelioma, osteoid osteoma/osteoblastoma/cementoblastoma and proliferative myositis/fasciitis. In this review, we provide an overview of FOS and FOSB, including their functions and the differences between lesions with known FOS/FOSB gene rearrangements. Additionally, we discuss the use of FOS/FOSB immunohistochemistry as a diagnostic tool for these lesions.

  • soft tissue neoplasms
  • bone and bones
  • molecular biology
  • immunohistochemistry

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  • Handling editor Vikram Deshpande.

  • Contributors FC performed the writing of the paper and made the figures. DC performed the study concept, design and review of the paper. All authors read and approved the final paper.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; externally peer reviewed.