Aims Recent clinical trials have shown promising results with drugs targeting the hepatocyte growth factor receptor (c-Met) for advanced non-small cell lung cancers overexpressing c-Met. We assessed reflex testing of c-Met immunohistochemistry (IHC) at diagnosis for NSCLC in the real-world.
Methods We retrospectively collected clinical, pathological and molecular data of cases diagnosed with NSCLC in our institution from January 2021 to June 2023. We performed c-Met IHC (SP44 clone) and scored the expression using a H-score and a three-tier classification.
Results 391 cases with interpretable c-Met IHC staining were included. The median age at diagnosis was 70 years (range 25–89 years) including 234 males (male/female ratio 1:5). 58% of the samples came from surgical resections, 35% from biopsies and 8% from cytological procedures. 52% of cases were classified as c-Met-positive (H-score≥150) and 19% were classified as c-Methigh (≥50%, 3+). 43% of the c-Metneg presented with lymph node and/or visceral metastases at diagnosis vs 55% for c-Methigh (p=0.042). 23% of the adenocarcinomas showed c-Methigh expression vs 3% for squamous cell carcinomas (p=0.004). 27% of the c-Metneg cases had a high PD-L1 expression vs 58% of c-Methigh cases (p<0.001). MET ex14 skipping was present in 8% of the c-Methigh cases.
Conclusions Systematic c-Met testing in daily routine for NSCLC patients is feasible, highlighting a potential correlation with clinicopathological and molecular features.
- LUNG CANCER
- Lung Neoplasms
Data availability statement
Data are available on reasonable request.
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Handling editor Runjan Chetty.
CB and VH contributed equally.
Contributors CB: data curation, analyses, graphic design, reviewing and editing: VH: writing of the original draft, resources, reviewing; MA: data collection, reviewing and editing; VL-F: data collection, reviewing and editing; SLalvée: data collection, reviewing and editing; SG: reviewing and editing; OB: data collection, reviewing and editing; EL-M: reviewing and editing; SLassalle: reviewing and editing; FM: reviewing and editing; GR: reviewing and editing; SH: reviewing and editing; MI: reviewing and editing; PH: supervision, administration, resources, reviewing and editing. PH is the author responsible for the overall content a the guarantor.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
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