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Recently, Pepper et al investigated the expression of the S100 protein in pancreatic neuroendocrine tumours (NETs).1 They found a significantly higher rate of S100 expression (58%) in pancreatic NETs in comparison with NETs from other primary sites (14%) and a high specificity (94%) of moderate to strong (score 2+/3+) expression of S100 protein to indicate a pancreatic origin of a NET. Concurrently but independently of Pepper et al’s study, we observed the expression of the S100 protein in some NETs of the ampullary region, which had not been investigated in the aforementioned study. Consequently, we performed an immunohistochemical analysis of S100 expression in 28 well-differentiated ampullary NETs (23 cases from the major ampulla and 5 cases from the minor papilla/ampulla), which were included in previously published multicentre studies on ampullary NETs2 3 and had available tumour tissue sections. Immunohistochemistry was performed …
Footnotes
Handling editor Yoh Zen.
Contributors Conception—AV, FI, SLR and GR. Data collection—AM and AC. Histological review—AV, FI, PP, LA, FG and SU. Immunohistochemical evaluation—AV, FI, PP, LA and PS. Interpretation—AV, FI, FG and MF. Manuscript writing (first draft)—AV, FI and GR. Manuscript writing (review and editing)—SLR, FG, SU and MF. Supervision—AV, FI and GR. Guarantor—FI.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; internally peer reviewed.