You are here

Article Text

Article menu
Download PDFPDF
Gene of the month
EWSR1: the promiscuous king of mesenchymal neoplasia
  1. Emily Anne Towery,
  2. David James Papke
  1. Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA
  1. Correspondence to Dr David James Papke, Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA; dpapke{at}bwh.harvard.edu

Abstract

EWSR1 is the most commonly rearranged gene in mesenchymal neoplasia, and its myriad chimeric oncoproteins drive widely disparate neoplasms. Here, we survey selected EWSR1 rearrangements, including well-described EWSR1 fusions with CREB family members, ATF1 and CREB1, as well as fusions in emerging entities such as mesenchymal neoplasms with EWSR1::PATZ1 and EWSR1::NFATC2 fusions. We also discuss recent data demonstrating the imperfect specificity of EWSR1::WT1 and, possibly, EWSR1::FLI1 fusions.

  • Pathology, Surgical
  • Sarcoma
  • Soft Tissue Neoplasms

https://doi.org/10.1136/jcp-2023-208867

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Handling editor Vikram Deshpande.

    • X @EToweryMD, @PapkeDavid

    • Contributors EAT and DJP wrote and edited the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Commissioned; externally peer reviewed.