You are here

Article Text

Article menu
Download PDFPDF
Letter
Histone antibodies in primary Sjögren’s disease
  1. Adrian Y S Lee1,2
  1. 1Westmead Institute for Medical Research, The University of Sydney, Westmead, New South Wales, Australia
  2. 2Department of Immunology & Immunopathology, Westmead Hospital and Institute of Clinical Pathology and Medical Research, Westmead, NSW, Australia
  1. Correspondence to Dr Adrian Y S Lee; adrian.lee1{at}sydney.edu.au

https://doi.org/10.1136/jcp-2024-209803

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Histone proteins serve as structural proteins that enable DNA to wrap around and organise molecularly. IgG antibodies towards histones (anti-histone antibodies; AHAs) are classically found in systemic lupus erythematosus (SLE) and drug-induced lupus, and may be associated with lupus nephritis and other disease manifestations in the former.1 However, AHAs do not specifically diagnostic for these conditions and can appear in a variety of other autoimmune disorders.1

    Sjögren’s disease (SjD) is a common chronic autoimmune systemic disease characterised by sicca symptoms, fatigue and B cell hyper-reactivity. AHAs have been identified in SjD patients previously2; however, the prevalence of AHAs and clinical relevance has never been systematically examined. Therefore, we undertook a cross-sectional study of a single-centre cohort of SjD patients in Australia to examine these aspects. Over a 12-month period, the clinical immunology clinics at Westmead Hospital in Sydney, Australia recruited consecutive primary SjD cases that met the ACR/EULAR SjD classification criteria.3 Patients were excluded from analyses if they had an overlap syndrome with SLE (n=12) or other systemic autoimmune diseases as this study …

    View Full Text

    Footnotes

    • Handling editor Patrick J Twomey.

    • Contributors AYSL: concept, data analyses, draft manuscript, guarantor.

    • Funding This work was supported by a Postgraduate Scholarship from the National Health and Medical Research Council (AL)–Award Number 2013839.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.