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Original research
Primary melanoma of the urinary tract: a clinicopathological study of cases and literature review
  1. Lisha Wang,
  2. Mohammed Wali,
  3. Yue Sun
  1. Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
  1. Correspondence to Dr Yue Sun; ysun{at}bidmc.harvard.edu

Abstract

Aim Primary malignant melanomas in the bladder or urethra are exceedingly rare. Diagnosing these tumours presents substantial challenges due to their close resemblance in gross appearance and histology to urothelial carcinomas.

Methods A retrospective review of our department archives from 2000 to 2023 identified four cases of primary malignant melanoma in the urinary tract. Demographic and clinical data were extracted from electronic medical records.

Results This retrospective case series investigates the clinical presentations, histopathological characteristics, immunohistochemical profiles and molecular features of four unique cases of primary malignant melanoma in the bladder or urethra.

Conclusion Our analysis aims to deepen the understanding of the diagnostic and management strategies for this extremely rare disease.

  • MELANOMA
  • Urinary Bladder
  • Pathology, Molecular

Data availability statement

Data are available in a public, open access repository.

https://doi.org/10.1136/jcp-2024-209684

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    Data availability statement

    Data are available in a public, open access repository.

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    Footnotes

    • Handling editor Murali Varma.

    • X @lishawang9

    • Contributors Conception or design of the work: YS. Data collection: LW, MW and YS. Data analysis and interpretation: LW, MW and YS. Drafting the article: LW and YS. Final approval of the version to be published: all authors. YS is responsible for the overall content as the guarantor.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.