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Research Article
Incomplete anaerobiosis as a cause of metronidazole 'resistance'.
  1. S E Milne,
  2. E J Stokes,
  3. P M Waterworth

    Abstract

    Clostridium welchii, used as a control, was found to grow well in a microaerophilic jar used for campylobacters but appeared resistant to a metronidazole disc although the campylobacter was sensitive. Minimum inhibitory concentrations for six strains of Cl. welchii were up to 64-fold higher in these conditions than when grown anaerobically. Zones of inhibition with both Cl. welchii and Bacteroides fragilis varied with the amount of air admitted to anaerobic jars.

    https://doi.org/10.1136/jcp.31.10.933

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