Is there really anything new under the sun?¹ I wondered, as I was asked to select a chemical pathology paper from the first volume of the first edition of JCP, to discuss in the millennium issue of the journal. Furthermore, would it be possible for me to find a paper from over 50 years ago that would reflect chemical pathology practice at the time and contrast this with current trends in the field as we lead up to the millennium celebrations? A paper that did stand out was that by E J King and R J Garner, from the British Postgraduate Medical School, entitled “The colorimetric determination of glucose.”² This was starkly different from those current papers that one tends to browse through, describing knock out …