eLetters

39 e-Letters

published between 2001 and 2004

  • Reliability of prognostic factors in breast needle core biopsies.
    Jeffrey M. Theaker

    Dear Editor

    The reliability of diagnostic and prognostic information in breast core biopsies is an important factor to be considered by surgeons and oncologists when planning treatment, especially if pre-operative chemotherapy is under consideration. The recent report by O’Leary et al.[1] is important because it considers whether the amount of tumour present in core biopsies has any impact upon the reliabi...

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  • The bombesin/GRP antagonist RC-3095 in a patient with the Zollinger-Ellison syndrome
    Gilberto Schwartsmann

    Dear Editor

    We read with interest the article by Scott and cols. in the February, 2004 issue of JCP, in which the expression of gastrin-releasing peptide and gastrin-releasing peptide receptors in gastrointestinal carcinoid tumors is discussed.[1]

    Currently, we are completing a Phase I trial with the new synthetic bombesin/gastrin-releasing peptide antagonist RC-3095 in patients with advanced refractory solid m...

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  • Does normal C4 exclude hereditary angioedema (HAE)?
    Robert J Lock

    Dear Editor

    We read with interest the case report from Karim and colleagues in the Journal.[1] This case raises an important issue.

    Our study [2] has been quoted as suggesting that we have described HAE with normal C4. We do not entirely accept this interpretation. Although there were HAE patients with normal C4 this was only achieved whilst on adequate treatment. All 20 HAE patients in whom we were able...

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  • The authors must show that their findings hold true in vivo.
    George Hill

    Dear Editor

    Soilleux & Coleman report a study related to human immunodeficiency virus (HIV) infection through the human foreskin [1] They do not state whether the foreskin tissue was harvested from immature infants or from sexually mature adult males. Immature tissue may behave differently from mature tissue.

    Caution must be observed when assuming in vitro viral behaviour is equivalent in vivo....

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  • Author's reply to Zardawi
    Tadashi Hasegawa

    Dear Editor

    We appreciated the comments of Dr Zardawi [1] and agree that actin is a ubiquitous cytoskeletal protein of microfilaments and demonstrable in a variety of cells and tumor types. As we described, all leiomyosarcomas are smooth muscle actin (SMA)-positive, and desmin, muscle specific actin (MSA) and h-caldesmon are positive in a great majority of these tumors. However, none of these is absolutely specifi...

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  • Importance of mitochondrial function in SIDS
    Richard G Fiddian-Green

    Dear Editor

    May I draw your readers attention to two statements concerning SIDS made in electonic letters published in the British Medical Journal.

    "The probability is that SIDS is caused by the occult presence of an impairment of mitochondrial oxidative phosphorylation either inherited from the mother or acquired in utero, during parturition and/or after birth. In which case its presence should be detect...

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  • Re: Expression of smooth muscle markers in so called malignant fibrous histiocytoma
    Ibrahim M Zardawi

    Dear Editor

    I read with interest the article on the expression of smooth muscle markers in so called malignant fibrous histiocytomas by Hasegawa et al. in the Journal.[1]

    While I agree with Hasegawa and colleagues that pleomorphic malignant fibrous histiocytoma can be regarded as an undifferentiated sarcoma, I feel Hasegawa et al are placing too much reliance on so called smooth muscle markers. Most...

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  • Resolution
    Lodewijk Cobben

    Dear Editor

    In the results you mentioned that metastases couldn't be detected by PET because they were to small. I don't understand how this has anything to do with the resolution or collimation of the PET scanner. The resolution is something that is part of the scanner and has to do with the "pictures" that come out. Large detectors can also detect small abnormalities. Isn't detectabilty in PET scanning more depen...

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  • The Role of Mast Cells in Bone Marrow Diseases
    Öner Özdemir

    Dear Editor

    We read the article by Horny et al. describing bone marrow mast cell (MC) specific protease expression patterns in cases of systemic mastocytosis and myelodysplastic syndromes (MDS) with great interest.[1] Increase in bone marrow MC is a known feature of various hematological diseases including myeloproliferative disorders and acquired severe aplastic anemia (SAA). Although the MC increase is clona...

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  • Author's Reply
    G.S. Mijnhout

    Dear Editor

    We thank Dr Belhocine for his interest in and response to our article “How morphometric analysis of metastatic load predicts the (un)usefulness of PET-scanning: the case of lymph node staging in melanoma”.[1]

    The study includes 308 primary melanoma patients undergoing wide local excision and sentinel node biopsy, without palpable regional lymph nodes or evidence of distant relapse. All patients...

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