eLetters

59 e-Letters

published between 2005 and 2008

  • As inflammation is turned off, ME/CFS is turned on
    Sidsel E. Kreyberg
    Dear Editor

    Persistent enteroviral infection in gastric tissue is found in a high percentage of cfs-patients by Chia & Chia (Sept. 13, 2007) while histological changes are not specifically addressed in this paper. A comparison between cfs - and non-cfs enterovirus positive patients with regard to local inflammatory reaction would be of interest, though, as the lack of a proper inflammatory response to infectious agents...

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  • HUMAN PAPILLOMAVIRUS AND CANCER PREVENTION
    Dhruvashree Somasundara

    Dear Editor

    HPV (Human Papilloma Virus) is known to be related to cancers for a long time. However it was only recently that breakthrough has been made to introduce vaccines that can prevent HPV infection. The reason for this is that HPV infections are rarely, if ever, immediately ife-threatening. Vaccination has always focused towards preventing causes of immediate death or disability.

    The importance...

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  • Non-invasive estimation of glioma proliferation by 99mTc-Tetrofosmin brain SPECT
    GEORGE A ALEXIOU

    Dear Editor

    An interesting recent article by Sheehan et al. in your journal investigated whether the MIB-1 (Ki-67) labelling index in astrocytoma tissue cores – designed to replicate unrepresentative biopsies – could provide valuable information concerning tumor grade. The authors studied 134 cases of glioma and found that Ki-67 may be used to exclude low-grade astrocytoma, but cannot be used to distinguish between gli...

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  • Formalin fixation is not the be all and end all
    ReeNee Tiam

    Dear Editor

    The histopathological assessment of prognostic factors in rectal cancer is important in guiding management. One of these factors is the circumferential resection margin (CRM). The involvement of CRM by tumour indicates a high risk of local recurrence, and is also an indicator of the quality of surgery performed1. Eid et al2 attempted to investigate the effects of processing variability on the assessment of...

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  • Severity of dog bites
    Kenneth A Hoekstra, PhD

    Dear Editor

    In the article by Wareham et al. (1) the authors discuss a case report of atypical endocarditis following innoculation of Capnocytophaga canimorsus from a dog bite, and briefly review the history and management of C. canimorsus infections. There are numerous reports describing the association between the normal flora, gram-negative rod, C. canimorsus and human cardiovascular pathology (2-6). A recent report...

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  • Adenocarcinoma arising in a gastrocystoplasty
    Kenneth D Ivil

    Dear Editor

    We read with interest the case report of an adenocarcinoma arising in a gastrocystoplasty [1]. The authors also mention another report of a transitional cell carcinoma developing within a gastrocystoplasty [2] . We would like to point out however that a signet ring cell variant of adenocarcinoma within a gastrocystoplasty has also been described [3]. Briefly a 36-year-old man presented with renal failure...

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  • Serum 25(OH)D levels in breast cancer patients with bone metastases
    Christine E Simmons

    Dear Editor

    We read with interest the study reported by Palmieri et al in the January 10th issue of this journal.1 In their study, serum calcium, PTH and 25(OH)D levels were measured prospectively in 279 Caucasian women with breast cancer, 75 of whom had locally advanced or metastatic disease, but patients receiving bisphosphonates were excluded. Overall, the authors found that women with early-stage breast c...

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  • Immunocytochemistry and In-Situ Hybridisation on bone marrow trephine biopsy
    Lynne Doverty

    Dear Editor

    The world literature clearly recognises the role of the bone marrow trephine (BMT) biopsy in the investigation of haematological disorders and its flexibility in providing both diagnostic and prognostic information, an example of which appeared in the August edition of this journal This article gives an excellent account of the methodology employed and the accompanying illustrations clearly demonstrate th...

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  • Field change of apoptosis resistance in colonic mucosa of patients with colorectal carcinoma
    Claire M. Payne

    Dear Editor

    We are writing with respect to the following article: S Badvie, A Hanna-Morris, HJN Andreyev, P Cohen, S Saini, and TG Allen-Mersh A “field change” of inhibited apoptosis occurs in colorectal mucosa adjacent to colorectal adenocarcinoma. J Clin Pathol 2006:59: 942-946. We agree with the authors’ main conclusion that their findings are consistent with a field change of inhibited apoptosis in mucosa adjacent...

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  • The double-edged sword of HPV vaccination
    Kenneth A Hoekstra, PhD

    Dear Editor,

    M. Stanley has summarized and reviewed the importance of the recently available human papillomavirus (HPV) vaccine 1. In addition to this summary, I would like to stress the importance of the significant education initiatives that will be necessary to implement the success of the HPV vaccination. Yes, the vaccination may have the ability to reduce up to 70% of the HPV-associated cervical cancers...

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