eLetters

165 e-Letters

  • Re: Chronic fatigue syndrome and immune dysfunction : cause or effect?
    Paul Schaafsma

    Dear Editor

    Ian Chandler's response to this study, insisting that any immune abnormality is secondary to depression is without scientific merit.

    Several studies comparing ME/CFIDS patients with patients suffering from clinical depression have found important physical differences. SPECT brain imaging studies sh...

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  • Chronic fatigue syndrome and immune dysfunction : cause or effect?
    IAN P CHANDLER

    Dear Editor

    Having read Kennedy et al's short report on finding increased neutrophil apoptosis in patients with chronic fatigue syndrome, I am unable to agree with their conclusion that "these findings provide new evidence that patients with CFS have an underlying abnormality in their immune cells" [1]. They provide no evidence that the immune defect is causative, and, on the contrary, there is a wealth of...

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  • Controversial insights for lymphangiogenesis in breast cancer
    Fernando C. Schmitt

    Dear Editor

    Recently, we read with the interest the paper Lack of lymphangiogenesis during breast carcinogenesis from Vleugel et al. (J Clin Pathol.2004; 57: 746-751) [1]. These authors investigated the role of lymphangiogenesis in breast carcinogenesis. Whist the resident lymphatics and/or new tumour-induced lymphatic vessels are collapsed by the intra- tumoral pressure, or if they do facilitate the neopl...

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  • Value of Specimen Mammography
    Obi C Iwuagwu

    Dear Editor

    I read with interest the recent article by Cook et al. and do agree that examination of breast reduction specimen is beneficial since incidental malignancy/high risk lesions are well documented.The problem has often been one of examination of relatively large breast reduction specimens with attendant time and resource constraints, often requiring random sampling.

    Specimen mammography (...

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  • A study of public opinion on the use of tissue samples from living subjects for clinical research
    Peter Furness

    Dear Editor

    The paper by Goodson and Vernon on public opinions of tissue sample use,[1] contains a fundamental flaw which, unless I am mistaken, ought to have prevented its publication.

    It is generally accepted that post mortem tissue has much greater emotional significance than samples of human tissue removed from living patients. This is supported by a survey of public opinion conducted by the MRC a...

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  • The rise of the dangerous cult of splenic preservation
    Richard G Fiddian-Green

    Dear Editor

    The fear of overwhelming infection following splenectomy has had a profound and detremental effect upon the recent evolution of surgical practice. Extraordinary efforts to save the spleen are now the rule usually in the hands of trainees and inexperienced or inadequately trained surgeons. The methods include splenic repair, partial splenectomy, wrapping the spleen in a Dexon mesh, non-operative manageme...

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  • Reliability of prognostic factors in breast needle core biopsies.
    Jeffrey M. Theaker

    Dear Editor

    The reliability of diagnostic and prognostic information in breast core biopsies is an important factor to be considered by surgeons and oncologists when planning treatment, especially if pre-operative chemotherapy is under consideration. The recent report by O’Leary et al.[1] is important because it considers whether the amount of tumour present in core biopsies has any impact upon the reliabi...

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  • The bombesin/GRP antagonist RC-3095 in a patient with the Zollinger-Ellison syndrome
    Gilberto Schwartsmann

    Dear Editor

    We read with interest the article by Scott and cols. in the February, 2004 issue of JCP, in which the expression of gastrin-releasing peptide and gastrin-releasing peptide receptors in gastrointestinal carcinoid tumors is discussed.[1]

    Currently, we are completing a Phase I trial with the new synthetic bombesin/gastrin-releasing peptide antagonist RC-3095 in patients with advanced refractory solid m...

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  • Does normal C4 exclude hereditary angioedema (HAE)?
    Robert J Lock

    Dear Editor

    We read with interest the case report from Karim and colleagues in the Journal.[1] This case raises an important issue.

    Our study [2] has been quoted as suggesting that we have described HAE with normal C4. We do not entirely accept this interpretation. Although there were HAE patients with normal C4 this was only achieved whilst on adequate treatment. All 20 HAE patients in whom we were able...

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  • The authors must show that their findings hold true in vivo.
    George Hill

    Dear Editor

    Soilleux & Coleman report a study related to human immunodeficiency virus (HIV) infection through the human foreskin [1] They do not state whether the foreskin tissue was harvested from immature infants or from sexually mature adult males. Immature tissue may behave differently from mature tissue.

    Caution must be observed when assuming in vitro viral behaviour is equivalent in vivo....

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