eLetters

59 e-Letters

published between 2005 and 2008

  • Russell body gastritis
    Colin JR Stewart

    Dear Editor

    I read with interest the recent report of two cases of ‘Russell body gastritis’ by Paik and colleagues.[1] The authors described the association of their cases with Helicobacter pylori infection, and proposed that chronic infection by this organism may have caused the overproduction of immunoglobulins by the plasma cells leading to the conspicuous Russell body formation. The original report of Russell body g...

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  • Occult metastasis in early stage malignancies: More common than we think
    Chee Fui CHONG

    Dear Editor

    We read with interest the article by Mescoli et al. on the high prevalence of isolated tumours cells in regional lymph nodes from pN0 colorectal cancer (CRC). [1] Based on a detailed study of resected lymph nodes, Mescoli et al reported that more than 50% of pN0-CRC patients have isolated tumour cells (ITC) in the mesenteric lymph nodes and ITC status significantly correlated with cancer stage and vascular c...

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  • Substance P and cancer
    Kenneth A Hoekstra, PhD

    Dear Editor,

    In the current report by Nowicki et al. the authors review and discuss the probable role of substance P in childhood leukemias and solid bone cancers, and the use of substance P antagonists for treatment (1). As reviewed by the authors, there is much evidence to support a role for substance P in carcinogenesis. Others have suggested substance P may induce mitogenesis through activation of neurokinin-1 recep...

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  • Re: Assessment of the Cardiff nephrectomy cut-up protocol with total blocking of the renal sinus (1)
    Patricia Harnden

    Dear Editor

    This interesting paper raises important points regarding the staging of renal carcinomas using the TNM classification of malignant tumours (2). In particular, one of the take-home messages was the need for further clarification of the type of vessel that must be invaded for tumours to be staged as pT3b. In fact, clarifications regarding the staging system for renal tumours had been sought from the TNM com...

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  • Microbial pathogens and atherosclerosis
    Kenneth A Hoekstra, PhD

    Dear Editor

    In the article by Weiss et al. 'No evidence for a direct role of Helicobacter pylori and Mycoplasma pneumoniae in carotid artery atherosclerosis' the authors conclude that the absence and/or random distribution of select pathogens (i.e. H pylori and M pneumoniae) precludes their direct role in the development of atherosclerosis. Given the rather small sample size of this study (36 patients), and the larg...

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  • HIV enteropathy
    Philip A Batman

    Dear Editor

    Re: My Approach. An approach to duodenal biopsies

    We read with interest the section in this review of duodenal pathology describing AIDS enteropathy. However, the histological description of the lesion by Serra and Jani 1 does not accurately reflect the majority of literature on the subject and the comments regarding pathogenesis are confused.

    The pathogenesis of villous at...

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  • Oncocytic features in rectal adenocarcinoma
    Maria P. Foschini

    Dear Editor

    We read with interest the paper entitled “Rectal adenocarcinoma with oncocytic features: possible relationship with pre-operative chemoradiotherapy” published in the October issue of this journal (1). In this paper 5 cases of rectal carcinomas mainly composed of oncocytic cells are reported. All the five cases underwent radio and chemotherapy before surgery. The Authors suggest t...

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  • Re: Zhang H, Xu L, Xiao D et al. Fascin is a potential biomarker for early-stage
    Olorunda Rotimi

    Dear Editor

    I read with interest the article by Zhang et al published in the September 2006 issue of the Journal of Clinical Pathology (J Clin Pathol 2006;59:958–964.). The authors wrote on fascin, an actin-binding protein, as a potential biomarker for early-stage oesophageal squamous cell carcinoma. There are a number of methodological issues with the research and paper that potentially weakens their findings and int...

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  • Best Practice in Primary Care Pathology
    Philip H Evans

    Dear Editor

    Smellie et al, in their article Best Practice in Primary Care Pathology: Review 3(1) cite our article published in the BMJ in 1994.(2)

    Unfortunately they state that this was a study of “people referred from primary care to a hospital lipid clinic” and it wasn’t. Our study was, on the contrary, a review of computerised medical records of a group of patients with hyperlipidaemia in one general prac...

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  • A quality work?
    Jeevan P Marasinghe

    Dear Editor,

    Nakhleh R E (1) has excelled in giving us a brilliant account on the quality assuarance and improvement plan in surgical pathological reporting in a nutshell. An accurate, comprehensive, brief and timely surgical pathology report would always facilitate the optimum management of the patient and it would also satisfy the needs of the customer, in this case the clinician.Undoubtably all the clinicians...

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