eLetters

59 e-Letters

published between 2005 and 2008

  • Re: Basal-like breast carcinomas
    Rosella Silvestrini

    Dear Editor,

    I recently read the article, "Basal-like breast carcinomas; clinical outcome and response to chemotherapy" by Banerjee et al. (corresponding author, Prof. Smith), published online in Journal of Clinical Pathology on 23.03.06. I would like to point out that the authors incorrectly make reference to a paper of mine (reference 3), published in Journal of Clinical Oncology in 1995, in connection with g...

    Show More
  • Reimbursement for Assay Tests
    Gregory D. Pawelski

    Dear Editor,

    The traditional criteria ever used to evaluate laboratory tests has been the predictive 'accuracy' of the test.

    None of the available laboratory tests used in the selection of treatments for cancer patients have ever been tested for 'efficacy'. This includes estrogen receptor, progesterone receptor, Her2/neu, immunohistochemical staining for tumor classification, bacterial culture and sensi...

    Show More
  • Moving beyond the gross appearance: the value of an accurate histological analysis
    Fabio De Giorgio

    Dear Editor,

    We read with great interest the original article by Bernardi et al. [1] in the December 2005 issue of the Journal. According to literature previously published, the authors believe that necroscopy is the standard method to determine the cause of death when investigating clinicopathological discrepancies and the epidemiology of disease. They reviewed the provisional and final reports of necropsies per...

    Show More
  • The value of total IgE levels in the context of specific allergy
    Desa Lilic

    Dear Editor,

    Our best practice guidelines for the diagnosis of allergy advise that routine requesting of total IgE measurements is not necessary; instead we advise requesting allergen-specific IgE based on clinical findings. Khan et al. argue that measurement of total IgE levels permits ascertainment of possible false-negative or false-positive specific IgE results. However, the examples given provide only a circum...

    Show More
  • Thrombophilia screens
    David M Keeling

    Dear Editor,

    It was interesting to read the audit of thrombophilia screens [1]. It was however stated that "Only 11 of the 47 laboratories surveyed routinely carried out a total protein S assay" and "The BCSH guidelines suggest that only the total protein S assay should be used as a screening test, and if this is abnormal, then a free protein S assay should be performed”. In fact the guideline [2] does not recommend...

    Show More
  • The value of total IgE levels in the context of specific allergy
    Sujoy Khan

    Dear Editor,

    The article by WS Smellie and colleagues[1] recommends not requesting total IgE levels when requesting allergen specific IgE. We agree that total IgE on its own neither rules in nor rules out the diagnosis of allergy. However, total IgE levels are useful in the interpretation of specific IgE tests, because they permit the ascertainment of possible false-negative or false-positive results. Although thi...

    Show More
  • HIF-1 and cellular fate
    Richard G Fiddian-Green

    Dear Editor,

    The authors of this paper observe that, "The severity of hypoxia determines whether cells become apoptotic or adapt to hypoxia and survive. A hypoxic environment devoid of nutrients prevents the cell undergoing energy dependent apoptosis and cells become necrotic....During hypoxia, an intricate balance exists between factors that induce or counteract apoptosis, or even stimulate proliferation".[1]

    ...
    Show More
  • Seasonal variation in mortality from myocardial infarction and haemopericardium: a postmortem study
    Richard M Jones

    Dear Editor,

    I read with interest the recent article by Biedrzycki and Baithun[1] investigating the relationship between myocardial infarction complicated by haemopericardium, and season. The study utilised data collected during Coronial postmortem examinations, carried out over a 5-year period in East London. They concluded that there was indeed a ‘seasonal variation’ for this entity, and that the likelihood of ven...

    Show More
  • Specialist Registrar
    Runjan Chetty

    Dr Tandon: You should contact the RCPath directly and get a ruling pertinent to your qualifications and experience.

    Professor Runjan Chetty
    Editor, The Journal of Clinical Pathology

  • SpR in histopathology
    Nidhi Tandon

    Dear Editor,

    I gather from the article that an overseas graduate with an experience in Pathology can directly apply for SpR post, but the rcpath website says it is not so for histopathology. I would like to know if an overseas graduate with an experience in Pathology equivalent to the award of CCST can directly get into SpR post?

Pages