eLetters

158 e-Letters

  • Author’ Reply
    Gero Brockhoff

    We thank the reader for the careful and critical evaluation of our publication “Value of multicolor Fluorescence in situ Hybridization (UroVysionTM) in the differential diagnosis of flat urothelial lesions” published by Stephan Schwarz, Michael Rechenmacher, Tomas Filbeck, Ruth Knuechel, Hagen Blaszyk, Arndt Hartmann and Gero Brockhoff. The reader realized some inconsistency in the Material and Methods section of our paper r...

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  • Immunohistochemistry of HER2
    IRENA SREBOTNIK KIRBIŠ

    Dear Editor
    In the section Methods the authors described Immunohistochemistry of HER2. The described protocol is an inconsistent mixture of a manual and automated immunostaining procedure and it is very unlikely that it was actually applied.

    In a second sentence the authors stated that “a manual avidin-biotin peroxidase complex procedure was used in the immunohistochemical analysis according to the ma...

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  • On the inaccuracies in the literature on Salmonella meningitis in adults.
    Yuri Zagvazdin

    Dear Editor

    We read with interest the article by K. Swe Swe and coauthors (1), which enriches our knowledge about non-typhoidal salmonella meningitis. From our own experience, we know that there are unexpected difficulties in addressing some aspects of this rare disease, which may result in inaccuracies. The authors stated that 10 out of total 17 cases of this rare infection have been reported in adults lacking po...

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  • Human brucellosis - where, when, what and how?
    Sally J Cutler

    Dear Editor

    I fully endorse the recommendations of Reddy and co-workers concerning management of potential Brucella isolates and those staff potentially exposed 1. The authors highlight that clinical information may not always suggest potential brucellosis, especially if time has elapsed since exposure, thus suspicion may not be raised. The authors then proceed to describe four blood culture isolates obtained from patien...

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  • Re: JCV – what’s in a name?
    James J Clayton

    Dear Editor.

    I was interested to read the article by Zheng and colleagues in the July 2007 edition of the Journal of Clinical Pathology 1, wherein the authors describe detection of Jamestown Canyon virus in human tissue samples. I write to urge caution as I fear that a simple unfortunate error has been made.

    Jamestown Canyon virus is a bunyavirus belonging to the ‘California serogroup’, an enveloped, sing...

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  • Account must be taken, not only of non thyroidal illness but also of advanced age
    oscar,m jolobe

    Dear Editor,

    In the context of clinically suspected non-thyroidal illness(NTI) the advice to retest patients with raised levels of thyroid stimulating hormone(TSH)(1) may extend even to those in whom TSH levels are in the range 20-32.4 mIU/L(2). In one study, over a period averaging 88 days(Standard Error ie SE=34), seven such subjects, with mean baseline TSH of 32.4 mIU/L(SE=3.6), experienced a spontaneous fall in...

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  • Sputum sampling, storage and recovery: accuracy and sensitivity for Mycobacterium tuberculosis
    Kenneth Hoekstra

    Letter to the Editor - Sputum sampling, storage and recovery: accuracy and sensitivity for Mycobacterium tuberculosis

    Dear Editor,

    The recent article by Pye et al. discusses the recovery of bacteria from sputum specimen samples stored at different temperatures (1). This article highlights sample handling, storage and transport, from the field to the clinical laboratory. This may be important in the fiel...

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  • Estrogen receptor beta immunohistochemistry: time to get it right
    Valerie Speirs

    Dear Editor

    We read with interest the paper by Borgquist et al (2008), published recently in Journal of Clinical Pathology1. In their article the authors aimed to investigate the impact of ERbeta expression on breast cancer outcome using a cohort of 512 tumours represented in tissue microarray (TMA). Since the discovery of ERbeta over a decade ago, this has been the goal of many research groups. However pr...

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  • solitary cardiac metastatic tumour with unknown site of primary origin
    oscar,m jolobe

    Dear Editor

    Intracavitatory metastases may either be left-sided, as documented in a recent case report1, or right-sided, as documented in two previous case reports2,3, both cases in the latter two reports2,3 characterised by symptomatic right-sided cardiac failure attributable, in the second of the two cases to the fact that tumour cells originating from the right intracavitatory...

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  • TMPRSS2-ERG in Localized Parostate Cancer
    Tarek A. Bismar

    Dear Editor

    The TMPRSS2-ERG has been described in several prostate cancer patients' cohorts. The article by Ashish et al. describes the frequency of this fusion in another patient cohort. It further demonstrates that the frequency of TMPRSS2-ERG is increased in moderate to poorly differentiated tumors. We would like to congratulate the authors on their interesting study and advocate that more work still has to be carrie...

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