eLetters

165 e-Letters

  • Response from authors
    Emina A Torlakovic

    Dear Editor,

    We fully support the integrated approach to hematopathological diagnostics, which has been advanced by the WHO 2008 classification and we acknowledge the prominent role of immunophenotyping in this classification (1). The integrated approach is still not fully applied even in the most advanced countries. In some other countries, (hemato)pathologists still struggle, having only bone marrow (BM) tissue...

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  • Serrated and non-serrated polyps of the colorectum...
    Olorunda Rotimi

    Dear Editor,

    Re: Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenoma

    We read with interest the article by Carr NJ et al (J Clin Pathol 2009;62:516-518). The article describes the prevalence of different colorectal polyps in an unselected population with a focus speci...

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  • External QA for bone marrow biopsies. Why is there such a need?
    Attilio Orazi

    Dear Editor

    The authors use sweeping generalizations to make their case. This is just one example: "while the role of external quality assurance programs is well established as a valuable tool for QA/QC in diagnostic immunohistochemistry in surgical pathology, such approaches are notably lacking in bone marrow biopsy pathology". However, in reality, no published data support a need for an external QA/QC program fo...

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  • Peritoneal lymphomatosis with rasised CA125: cytology with flow cytometry helps in the diagnosis
    Hui-Hua Hsiao

    Dear Editor,

    Dr. Aslam presented a rare case with peritoneal lymphomatosis and concluded that a histologic examination is crucial in the diagnosis, while cytology might sometimes mislead the workup.1 However, we present here another such case with raised CA 125 and demonstrate that cytology with a flow cytometry examination can help in the diagnosis.

    This 44-year-old female suffered from autoimmune disord...

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  • Which is the cart and which the horse?
    Richard G Fiddian-Green
    Which is the cart and which the horse?

    Dear Editor,

    In HL-60 cells lovastatin reduces the intracellular pH in dose- dependent manner and the fall in pH correlates with the extent of DNA degradation (1). More importantly alkalinization suppresses lovostatin-induced apoptosis. A fall in pH is an indication of reductive stress, a stimulus for the expression of HIF, VEGF and NOS. A normal or elevated pH may also be nece...

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  • First case of nodal marginal zone B-cell lymphoma arising of intraparotidal Warthin's tumour
    Olivia ZIMMER

    Dear Editor

    Warthin tumor (WT) of the salivary gland (so called papillary cystadenoma lymphomatosum or adenolymphoma) is a benign neoplasm of the salivary gland epithelium with a proliferative epithelial component associated with a variably prominent stroma.[1] As reported by Saxena [1], histogenesis of this entity is very controversial. WT and malignant lymphoma are rarely associated, and most are examples of invo...

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  • Toxin production in fishing vessels
    Stephen J James

    Dear Editor,

    I was very interested to read your article which was based on work we carried out a number of years ago. We feel it is important that the safety aspects of handling fish under the conditions described in the work are widely publicised.

    If readers would like a more detailed account of the work carried out they will find it in: James, S.J., James, C , Jones, S & Swain, M.J. 2000 Toxin productio...

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  • Author’ Reply
    Gero Brockhoff

    We thank the reader for the careful and critical evaluation of our publication “Value of multicolor Fluorescence in situ Hybridization (UroVysionTM) in the differential diagnosis of flat urothelial lesions” published by Stephan Schwarz, Michael Rechenmacher, Tomas Filbeck, Ruth Knuechel, Hagen Blaszyk, Arndt Hartmann and Gero Brockhoff. The reader realized some inconsistency in the Material and Methods section of our paper r...

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  • Immunohistochemistry of HER2
    IRENA SREBOTNIK KIRBIŠ

    Dear Editor
    In the section Methods the authors described Immunohistochemistry of HER2. The described protocol is an inconsistent mixture of a manual and automated immunostaining procedure and it is very unlikely that it was actually applied.

    In a second sentence the authors stated that “a manual avidin-biotin peroxidase complex procedure was used in the immunohistochemical analysis according to the ma...

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  • On the inaccuracies in the literature on Salmonella meningitis in adults.
    Yuri Zagvazdin

    Dear Editor

    We read with interest the article by K. Swe Swe and coauthors (1), which enriches our knowledge about non-typhoidal salmonella meningitis. From our own experience, we know that there are unexpected difficulties in addressing some aspects of this rare disease, which may result in inaccuracies. The authors stated that 10 out of total 17 cases of this rare infection have been reported in adults lacking po...

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