64 e-Letters

published between 2004 and 2007

  • Reliability of prognostic factors in breast needle core biopsies.
    Jeffrey M. Theaker

    Dear Editor

    The reliability of diagnostic and prognostic information in breast core biopsies is an important factor to be considered by surgeons and oncologists when planning treatment, especially if pre-operative chemotherapy is under consideration. The recent report by O’Leary et al.[1] is important because it considers whether the amount of tumour present in core biopsies has any impact upon the reliabi...

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  • The bombesin/GRP antagonist RC-3095 in a patient with the Zollinger-Ellison syndrome
    Gilberto Schwartsmann

    Dear Editor

    We read with interest the article by Scott and cols. in the February, 2004 issue of JCP, in which the expression of gastrin-releasing peptide and gastrin-releasing peptide receptors in gastrointestinal carcinoid tumors is discussed.[1]

    Currently, we are completing a Phase I trial with the new synthetic bombesin/gastrin-releasing peptide antagonist RC-3095 in patients with advanced refractory solid m...

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  • Does normal C4 exclude hereditary angioedema (HAE)?
    Robert J Lock

    Dear Editor

    We read with interest the case report from Karim and colleagues in the Journal.[1] This case raises an important issue.

    Our study [2] has been quoted as suggesting that we have described HAE with normal C4. We do not entirely accept this interpretation. Although there were HAE patients with normal C4 this was only achieved whilst on adequate treatment. All 20 HAE patients in whom we were able...

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  • The authors must show that their findings hold true in vivo.
    George Hill

    Dear Editor

    Soilleux & Coleman report a study related to human immunodeficiency virus (HIV) infection through the human foreskin [1] They do not state whether the foreskin tissue was harvested from immature infants or from sexually mature adult males. Immature tissue may behave differently from mature tissue.

    Caution must be observed when assuming in vitro viral behaviour is equivalent in vivo....

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