eLetters

164 e-Letters

  • Re: JCV – what’s in a name?
    James J Clayton

    Dear Editor.

    I was interested to read the article by Zheng and colleagues in the July 2007 edition of the Journal of Clinical Pathology 1, wherein the authors describe detection of Jamestown Canyon virus in human tissue samples. I write to urge caution as I fear that a simple unfortunate error has been made.

    Jamestown Canyon virus is a bunyavirus belonging to the ‘California serogroup’, an enveloped, sing...

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  • Account must be taken, not only of non thyroidal illness but also of advanced age
    oscar,m jolobe

    Dear Editor,

    In the context of clinically suspected non-thyroidal illness(NTI) the advice to retest patients with raised levels of thyroid stimulating hormone(TSH)(1) may extend even to those in whom TSH levels are in the range 20-32.4 mIU/L(2). In one study, over a period averaging 88 days(Standard Error ie SE=34), seven such subjects, with mean baseline TSH of 32.4 mIU/L(SE=3.6), experienced a spontaneous fall in...

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  • Sputum sampling, storage and recovery: accuracy and sensitivity for Mycobacterium tuberculosis
    Kenneth Hoekstra

    Letter to the Editor - Sputum sampling, storage and recovery: accuracy and sensitivity for Mycobacterium tuberculosis

    Dear Editor,

    The recent article by Pye et al. discusses the recovery of bacteria from sputum specimen samples stored at different temperatures (1). This article highlights sample handling, storage and transport, from the field to the clinical laboratory. This may be important in the fiel...

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  • Estrogen receptor beta immunohistochemistry: time to get it right
    Valerie Speirs

    Dear Editor

    We read with interest the paper by Borgquist et al (2008), published recently in Journal of Clinical Pathology1. In their article the authors aimed to investigate the impact of ERbeta expression on breast cancer outcome using a cohort of 512 tumours represented in tissue microarray (TMA). Since the discovery of ERbeta over a decade ago, this has been the goal of many research groups. However pr...

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  • solitary cardiac metastatic tumour with unknown site of primary origin
    oscar,m jolobe

    Dear Editor

    Intracavitatory metastases may either be left-sided, as documented in a recent case report1, or right-sided, as documented in two previous case reports2,3, both cases in the latter two reports2,3 characterised by symptomatic right-sided cardiac failure attributable, in the second of the two cases to the fact that tumour cells originating from the right intracavitatory...

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  • TMPRSS2-ERG in Localized Parostate Cancer
    Tarek A. Bismar

    Dear Editor

    The TMPRSS2-ERG has been described in several prostate cancer patients' cohorts. The article by Ashish et al. describes the frequency of this fusion in another patient cohort. It further demonstrates that the frequency of TMPRSS2-ERG is increased in moderate to poorly differentiated tumors. We would like to congratulate the authors on their interesting study and advocate that more work still has to be carrie...

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  • As inflammation is turned off, ME/CFS is turned on
    Sidsel E. Kreyberg
    Dear Editor

    Persistent enteroviral infection in gastric tissue is found in a high percentage of cfs-patients by Chia & Chia (Sept. 13, 2007) while histological changes are not specifically addressed in this paper. A comparison between cfs - and non-cfs enterovirus positive patients with regard to local inflammatory reaction would be of interest, though, as the lack of a proper inflammatory response to infectious agents...

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  • HUMAN PAPILLOMAVIRUS AND CANCER PREVENTION
    Dhruvashree Somasundara

    Dear Editor

    HPV (Human Papilloma Virus) is known to be related to cancers for a long time. However it was only recently that breakthrough has been made to introduce vaccines that can prevent HPV infection. The reason for this is that HPV infections are rarely, if ever, immediately ife-threatening. Vaccination has always focused towards preventing causes of immediate death or disability.

    The importance...

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  • Non-invasive estimation of glioma proliferation by 99mTc-Tetrofosmin brain SPECT
    GEORGE A ALEXIOU

    Dear Editor

    An interesting recent article by Sheehan et al. in your journal investigated whether the MIB-1 (Ki-67) labelling index in astrocytoma tissue cores – designed to replicate unrepresentative biopsies – could provide valuable information concerning tumor grade. The authors studied 134 cases of glioma and found that Ki-67 may be used to exclude low-grade astrocytoma, but cannot be used to distinguish between gli...

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  • Formalin fixation is not the be all and end all
    ReeNee Tiam

    Dear Editor

    The histopathological assessment of prognostic factors in rectal cancer is important in guiding management. One of these factors is the circumferential resection margin (CRM). The involvement of CRM by tumour indicates a high risk of local recurrence, and is also an indicator of the quality of surgery performed1. Eid et al2 attempted to investigate the effects of processing variability on the assessment of...

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