PT  - JOURNAL ARTICLE
AU  - C. Choremis
AU  - V. Kyriakidès
AU  - E. Papadakis
TI  - Studies on the blood lipids and lipoproteins in thalassaemia and sickle cell anaemia
AID  - 10.1136/jcp.14.4.361
DP  - 1961 Jul 01
TA  - Journal of Clinical Pathology
PG  - 361--364
VI  - 14
IP  - 4
4099  - http://jcp.bmj.com/content/14/4/361.short
4100  - http://jcp.bmj.com/content/14/4/361.full
SO  - J Clin Pathol1961 Jul 01; 14
AB  - In Cooley's anaemia the serum lipid fraction, determined by chemical analysis, was found to be decreased. The lipoprotein distribution by paper electrophoresis showed a characteristic pattern with abnormally low α1 fraction and high concentrations of the β fractions. There is no relationship between age and serum lipoprotein distribution. A correlation was found between the electrophoretic pattern, liver function tests, and the E/C index. Similar changes but of lesser degree were found in sickle cell anaemia. Liver damage is thought to be the probable cause of the reduced α1 fraction.