PT  - JOURNAL ARTICLE
AU  - D. W. Evans
AU  - J. B. W. Halley
TI  - Wegener's granulomatosis: report of a patient surviving four and a half years
AID  - 10.1136/jcp.16.3.215
DP  - 1963 May 01
TA  - Journal of Clinical Pathology
PG  - 215--219
VI  - 16
IP  - 3
4099  - http://jcp.bmj.com/content/16/3/215.short
4100  - http://jcp.bmj.com/content/16/3/215.full
SO  - J Clin Pathol1963 May 01; 16
AB  - A patient with Wegener's granulomatosis, treated with steroids on a long-term basis, survived at least four and a half years from onset until death occurred in an uncontrollable exacerbation of the disease process. This is believed to be the longest recorded survival. Histological examination of the necropsy specimens suggests that the basic pathological lesion in this disease is the subendothelial deposition of so far unidentified material in the capillaries, arterioles, venules, and smaller arteries. The associated angiitis may be a consequence of this deposition. These vascular lesions are occulusive and adequately account for the observed infarctive changes. The granulomatous features of the disease probably represent a secondary reactive phenomenon.