%0 Journal Article %A J. N. Harris-Jones %A H. Miller %A G. Owen %T Insulin-binding antibodies in relation to insulin therapy %D 1963 %R 10.1136/jcp.16.2.120 %J Journal of Clinical Pathology %P 120-123 %V 16 %N 2 %X Methods for detecting insulin binding or transporting antibodies are described, involving the use of radioactively labelled insulin (insulin 131I). These antibodies are detected in a high proportion of patients receiving insulin, particularly those requiring large doses. The protein fractions concerned appear to be the beta and gamma globulins. The significance of the phenomenon is discussed. %U https://jcp.bmj.com/content/jclinpath/16/2/120.full.pdf