PT  - JOURNAL ARTICLE
AU  - N. MacKay
AU  - J. C. Ferguson
AU  - G. P. McNicol
TI  - Effects of three cobra venoms on blood coagulation, platelet aggregation, and fibrinolysis
AID  - 10.1136/jcp.22.3.304
DP  - 1969 May 01
TA  - Journal of Clinical Pathology
PG  - 304--311
VI  - 22
IP  - 3
4099  - http://jcp.bmj.com/content/22/3/304.short
4100  - http://jcp.bmj.com/content/22/3/304.full
SO  - J Clin Pathol1969 May 01; 22
AB  - The effects of the venoms of Naja melanoleuca, Naja nigricollis, and Ophiophagus hannah on blood coagulation, platelet aggregation, and fibrinolysis were studied in vitro. All three venoms were shown to be anticoagulant. This action appeared to be due to an effect on both the extrinsic and blood thromboplastin mechanisms. Platelet aggregation in Chandler's tubes and adenosine diphosphate reactivity were inhibited by the three venoms, although in the case of Ophiophagus hannah venom they were inhibited only with intermediate concentrations. The three venoms possessed proteolytic properties, but when incorporated into purified caseinolytic systems and euglobulin clot lysis systems inhibition of plasmin activity was observed.