PT - JOURNAL ARTICLE AU - J. H. Darrell AU - L. P. Garrod AU - Pamela M. Waterworth TI - Trimethoprim: laboratory and clinical studies AID - 10.1136/jcp.21.2.202 DP - 1968 Mar 01 TA - Journal of Clinical Pathology PG - 202--209 VI - 21 IP - 2 4099 - http://jcp.bmj.com/content/21/2/202.short 4100 - http://jcp.bmj.com/content/21/2/202.full SO - J Clin Pathol1968 Mar 01; 21 AB - Trimethoprim is a synthetic compound which arrests the step in bacterial purine synthesis immediately succeeding that interfered with by sulphonamides. Acting alone it inhibits the growth of a wide range of bacteria in generally much lower concentrations than sulphonamides. Its action with a sulphonamide is strongly synergic and bactericidal. Studies are described of suitable cultural conditions, methods of testing sensitivity, and acquired resistance. Some clinical results of its use are reported in respiratory tract infections, Gram-negative septicaemia, and urinary tract infections, and further therapeutic possibilities are discussed.